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    Biomedicine & Biotechnology

    Mid-IR fiber probes in cancer diagnostic

    FTIR spectroscopy possesses wide potential as the technique for difference between normal and neoplastic tissues. This technique, being reagent free, can rapidly and non invasively detect changes in the biochemical composition of cells and tissues at the molecular level.       

    Areas where FTIR-spectroscopy may be used in cancer diagnosis are:

     •   Differentiation of normal and diseased tissues in organs, detection of early stages of malignancy

     •   Monitoring abnormal cell growth and proliferation in tissue sections 

     •   Distinguishing between normal and abnormal cell-cell scrapings & biopsies from smaller organs   

     •   Differentiation between cancer and other pathologic conditions with similar clinical manifestation

     •   Monitoring the effect of anticancer therapy – chemotherapy

    Related publications

     

    • Detection of colonic inflammation with Fourier transform infrared spectroscopy using a flexible silver halide fiber

    Vinay K. Katukuri, John Hargrove, Sharon J. Miller, Kinan Rahal, John Y. Kao, Rolf Wolters, Ellen M. Zimmermann and Thomas D. Wang
    Biomed Opt Express. 2010 October 1; 1(3): 1014–1025

    • Fiber-optic probes enable cancer detection with FTIR spectroscopy

    Mackanos MA, Contag CH
    Trends in biotechnology, Volume 28, Issue 6, June 2010, Pages 317–323

    • In vivo and in situ detection of colorectal cancer using Fourier Transform Infrared Spectroscopy

    Li QB, Xu Z, Zhang NW, Zhang L, Wang F, Yang LM, Wang JS, Zhou S, Zhang YF, Zhou XS, Shi JS, Wu JG
    World Journal of Gastroenterology: WJG 2005, 11(3):327-330

    • Noninvasive biochemical monitoring of physiological stress by Fourier transform infrared saliva spectroscopy

    S. Khaustova, M. Shkurnikov, E. Tonevitsky, V. Artyushenko, A. Tonevitsky
    Analyst, 2010,135, 3183-3192